This article may interest you, if when you double click an Excel (.xls or .xlsx), Word (.doc or .docx) or PowerPoint (.ppt or .pptx) 2010 file and it fails to open.
You may experience any of these problems:
1. The file icon is blank or displays an incorrect image.
2. The file does not open.
3. You receive this error: This file does not have a program associated with it for performing this action. Create an association in the Folder Options control panel.
4. You receive this error: not a valid Win32 Application
You experirnce this issue, when the association between the file and the corresponding application is missing.
To reolve this issue, visit Microsoft KB2464297 and follow the methods outlined.