Fix: Error code ‘0x80070646’, ‘646’ or ‘1606’ when you try to install Office updates

This article may interest you, if when you try to install updates for Microsoft Office applications via Windows Update or Microsoft Update and you receive one of the following error codes; 0x80070646, 646, or 1606.

This update problem occurs when Windows Installer encounters an error. Error code 0x80070646 and error code 646 are generated by Windows Installer. These generic errors indicate that Windows Installer encountered a problem.

The problem may be caused by an incorrect value in the registry.

To resolve this issue, you will need to automatically/manually update the affected registry keys.

Check out Microsoft KB2258121 for steps on resolving this issue.

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